Insights: Publications Protecting Deuterated Drugs

Intellectual Property Magazine

Deuterium (2H) is a nonradioactive isotope of hydrogen that contains a neutron in addition to hydrogen’s proton and electron. Deuterium can covalently bind to other atoms in the same manner as hydrogen. Because deuterium and hydrogen are essentially the same size, a deuterated compound and its hydrogen-containing (proteo) counterpart may bind similarly to a biological target, such as a protein relevant to treating disease. However, deuterium is heavier than hydrogen and can form stronger bonds with carbon. These differences can give rise to differences in pharmacological properties.

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